Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 11/20 | 0.50 |
| ▸ | MMP13 | P45452 | 2/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP7 | P09237 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970842 | 0.85 | MMP2 (0.53) | MMP2ADAM17MMP13MMP3MMP7 | |
| SCHEMBL3970211 | 0.82 | ADAM17 (0.57) | MMP2ADAM17MMP13MMP3MMP7 | |
| SCHEMBL3964650 | 0.81 | MMP2 (0.53) | MMP2ADAM17MMP13MMP3MMP7 | |
| SCHEMBL3964657 | 0.81 | MMP2 (0.53) | MMP2ADAM17MMP13MMP3MMP7 | |
| SCHEMBL3970844 | 0.81 | MMP2 (0.53) | MMP2ADAM17MMP13MMP3MMP7 | |
| SCHEMBL3969746 | 0.78 | ADAM17 (0.61) | MMP2ADAM17MMP13MMP3MMP7 | |
| SCHEMBL6632245 | 0.76 | ADAM17 (0.63) | MMP2ADAM17MMP13MMP3MMP7 | |
| SCHEMBL8353322 | 0.75 | ADAM17 (0.62) | MMP2ADAM17MMP13MMP3MMP7 | |
| SCHEMBL5887602 | 0.74 | ADAM17 (0.61) | MMP2ADAM17MMP13MMP3MMP7 | |
| SCHEMBL5887895 | 0.74 | ADAM17 (0.61) | MMP2ADAM17MMP13MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770647-B2 | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-03 | — | — | US | disclosed |
| WO-2003016248-A2 | BICYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-$G(A) CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY PATENT DEPARTMENT (US) | 2003-02-27 | — | — | WO | disclosed |