Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.67 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.67 |
| ▸ | GSK3B | P49841 | 14/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TOP2A | P11388 | 2/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680239 | 0.92 | KCNH2 (0.56) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL679183 | 0.87 | CACNA1F (0.48) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL9522715 | 0.87 | CACNA1F (0.76) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL10679561 | 0.84 | CACNA1F (0.78) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL10686828 | 0.84 | CACNA1F (0.74) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL10701879 | 0.83 | POLB (0.71) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL9570692 | 0.83 | ALDH1A1 (0.57) | POLBKCNH2MEN1KMT2ATOP2A | |
| SCHEMBL680228 | 0.83 | ALDH1A1 (0.57) | POLBKCNH2MEN1KMT2ATOP2A | |
| SCHEMBL8982806 | 0.83 | ALDH1A1 (0.57) | POLBKCNH2MEN1KMT2ATOP2A | |
| SCHEMBL9779815 | 0.83 | CACNA1F (0.68) | CACNA1FPOLBMAPK1CACNA1DKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108557-A1 | FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS | ALCON RESEARCH, LTD. (US) | 2012-05-03 | — | — | US | disclosed |
| US-20120108557-A1 | FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS | ALCON RESEARCH, LTD. (US) | 2012-05-03 | — | — | US | disclosed |
| US-20110160172-A1 | FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS | ALCON RESEARCH, LTD. (US) | 2011-06-30 | — | — | US | disclosed |
| US-20090209574-A1 | FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS | ALCON RESEARCH, LTD. (US) | 2009-08-20 | — | — | US | disclosed |
| US-20090209574-A1 | FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS | ALCON RESEARCH, LTD. (US) | 2009-08-20 | — | — | US | disclosed |
| WO-2009103053-A1 | FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS | ALCON RESEARCH, LTD. (US) | 2009-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160172-A1 | FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS | QARS1, UACA, CYP51A1 | CACNA1F 3937/4885POLB 276/4885MAPK1 1605/4885 |
| US-20090209574-A1 | FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS | QARS1, UACA, CYP51A1 | CACNA1F 3937/4885POLB 276/4885MAPK1 1605/4885 |
| US-20120108557-A1 | FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS | QARS1, UACA, CYP51A1 | CACNA1F 3937/4885POLB 276/4885MAPK1 1605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.