Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 2/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2790491 | 0.85 | KCNH2 (0.46) | TP53KDM4EPARP1L3MBTL1ENPP3 | |
| SCHEMBL2711191 | 0.82 | ELANE (0.48) | ELANETP53TNKSTNKS2PARP2 | |
| SCHEMBL2709066 | 0.81 | ELANE (0.47) | ELANETP53TNKSTNKS2PARP2 | |
| SCHEMBL11836535 | 0.81 | NT5E (0.46) | KDM4EKMT2AMEN1PARP1ENPP3 | |
| SCHEMBL7235527 | 0.80 | TNKS (0.44) | TNKSTNKS2PARP2KDM4EKMT2A | |
| SCHEMBL7220879 | 0.80 | MEN1 (0.39) | ELANEKDM4EKMT2AMEN1ENPP3 | |
| SCHEMBL7219924 | 0.78 | TP53 (0.54) | ELANETP53TNKSTNKS2PARP2 | |
| SCHEMBL7218856 | 0.78 | ELANE (0.43) | ELANETP53TNKSTNKS2PARP2 | |
| SCHEMBL6918746 | 0.75 | ALDH1A1 (0.41) | TP53KDM4EPARP1L3MBTL1ENPP3 | |
| SCHEMBL7208047 | 0.75 | KDM4E (0.42) | ELANETP53TNKSTNKS2PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004087670-A1 | PROCESS FOR SYNTHESIS OF BIS-(SUBSTITUTED 4 QUINOLYL) DISULPHIDES | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2004-10-14 | — | — | WO | disclosed |
| US-6777553-B1 | USING SUBSTITUTED-4-HALOQUINOLINES AND THE SODIUM, POTASSIUM OR AMMONIUM SALTS OF DITHIOCARBAMIC ACID WHICH AVOIDS THE HANDLING OF HAZARDOUS AND CORROSIVE CHLOROSULPHONIC ACID | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2004-08-17 | — | — | US | disclosed |
| US-6583156-B1 | Particularly adenosine A2A receptors; neurodegenerative disorders; 2,8-bis(trifluoromethyl)-alpha -(3-thienyl)-4-quinolinemethanol | VERNALIS RESEARCH LIMITED (GB) | 2003-06-24 | — | — | US | disclosed |
| EP-1107760-A2 | 4-QUINOLINEMETHANOL DERIVATIVES AS PURINE RECEPTOR ANTAGONISTS (I) | VERNALIS RESEARCH LIMITED (GB) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000013681-A2 | 4-QUINOLINEMETHANOL DERIVATIVES AS PURINE RECEPTOR ANTAGONISTS (I) | VERNALIS RESEARCH LIMITED (GB) | 2000-03-16 | — | — | WO | disclosed |