Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN2 | Q16513 | 5/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.57 |
| ▸ | PIM1 | P11309 | 3/20 | 0.57 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.57 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.57 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.57 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.57 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 13/20 | 0.53 |
| ▸ | PKN1 | Q16512 | 4/20 | 0.52 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.52 |
| ▸ | CLK2 | P49760 | 2/20 | 0.52 |
| ▸ | GSK3A | P49840 | 2/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805372 | 0.95 | PKN2 (0.63) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6809854 | 0.91 | PIM1 (0.60) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6810110 | 0.88 | PIM1 (0.66) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6585579 | 0.88 | PKN2 (0.43) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6806567 | 0.85 | CHEK2 (0.42) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL3582877 | 0.83 | PARP1 (0.69) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6585966 | 0.83 | PKN2 (0.48) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6806262 | 0.83 | AURKB (0.57) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6806133 | 0.83 | PARP1 (0.75) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6809929 | 0.83 | PARP1 (0.65) | PKN2MAP4K4PIM1PIM3AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |