Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN2 | Q16513 | 4/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.48 |
| ▸ | PIM1 | P11309 | 3/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.48 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.48 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.41 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585579 | 0.95 | PKN2 (0.43) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6586038 | 0.91 | PIM1 (0.51) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6578295 | 0.89 | PARP1 (0.52) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6586074 | 0.88 | PIM1 (0.46) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6805372 | 0.88 | PKN2 (0.63) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6587758 | 0.84 | PARP1 (0.57) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6806556 | 0.83 | PKN2 (0.57) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6583719 | 0.83 | PARP1 (0.43) | PIM1PIM3AURKBCLK4STK17A | |
| SCHEMBL6588724 | 0.83 | PDE5A (0.51) | PKN2MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6587192 | 0.83 | PARP1 (0.50) | PIM1PIM3AURKBBRSK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |