Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 3/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.40 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.40 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 3/20 | 0.39 |
| ▸ | ATR | Q13535 | 2/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805384 | 0.95 | CLK4 (0.44) | CHEK2CLK4MAP4K4PIM1PIM3 | |
| SCHEMBL6809867 | 0.91 | CLK4 (0.42) | CHEK2CLK4MAP4K4PIM1PIM3 | |
| SCHEMBL6810124 | 0.88 | CLK4 (0.47) | CLK4MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6806556 | 0.85 | PKN2 (0.57) | CHEK2CLK4MAP4K4PIM1PIM3 | |
| SCHEMBL6806267 | 0.84 | HTR1A (0.43) | CLK4PIM1PIM3AURKBSTK17A | |
| SCHEMBL6809941 | 0.83 | PARP1 (0.48) | CHEK2PIM1PIM3AURKBBRSK1 | |
| SCHEMBL3582880 | 0.83 | ALDH1A1 (0.47) | CHEK2CLK4MAP4K4PIM1PIM3 | |
| SCHEMBL6806139 | 0.83 | IKBKB (0.52) | CLK4AURKBPKN2MKNK2PDE5A | |
| SCHEMBL6810121 | 0.83 | HTR1A (0.41) | CLK4PIM1PIM3AURKBSTK17A | |
| SCHEMBL6805803 | 0.83 | PARP1 (0.49) | CHEK2KDM4EPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |