Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14754412 | 0.77 | CYP19A1 (0.44) | KMT2ANOTUMMETAP2NPC1RAB9A | |
| SCHEMBL4587359 | 0.73 | NPC1 (0.36) | KMT2ANPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL10000254 | 0.67 | NPC1 (0.61) | KMT2APOLBNOTUMMETAP2METAP1 | |
| SCHEMBL12267118 | 0.67 | KMT2A (0.44) | KMT2APOLBNOTUMMETAP2METAP1 | |
| SCHEMBL6153838 | 0.67 | KMT2A (1.00) | KMT2APOLBNOTUMNPC1RAB9A | |
| SCHEMBL10205815 | 0.65 | CCR1 (0.55) | KMT2APOLBNOTUMMETAP2METAP1 | |
| SCHEMBL197731 | 0.64 | ACHE (0.73) | ENPP3ENPP1CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL3287696 | 0.64 | ACHE (0.73) | ENPP3ENPP1CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL18661495 | 0.64 | ACHE (0.73) | ENPP3ENPP1CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL11118103 | 0.64 | SMN1; SMN2 (0.43) | KMT2APOLBNOTUMNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040097730-A1 | Thrombin inhibitors | MERCK & CO., INC. | 2004-05-20 | — | — | US | disclosed |
| US-4636517-A | 3-tolylthio-4-amino-4,5-dihydro isoxazole as anthelmintic | INTERNATIONAL MINERALS & CHEMICAL CORP. (US) | 1987-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097730-A1 | Thrombin inhibitors | F3, F2, SERPINC1 | KMT2A 3143/4885POLB 3900/4885NOTUM 1910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.