Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.61 |
| ▸ | CTSL | P07711 | 3/20 | 0.37 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 6/20 | 0.36 |
| ▸ | MMP3 | P08254 | 6/20 | 0.36 |
| ▸ | MMP2 | P08253 | 3/20 | 0.36 |
| ▸ | MMP9 | P14780 | 3/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6670636 | 0.98 | TUBB1 (0.63) | TUBB1CTSLCTSBCTSSCTSK | |
| SCHEMBL6670644 | 0.98 | TUBB1 (0.63) | TUBB1CTSLCTSBCTSSCTSK | |
| Hydrochloric Acid SCHEMBL6807323 | 0.97 | TUBB1 (0.62) | TUBB1CTSLCTSBCTSSCTSK | |
| SCHEMBL6675810 | 0.90 | TUBB1 (0.61) | TUBB1CTSSCTSKMMP1MMP3 | |
| SCHEMBL6675817 | 0.90 | TUBB1 (0.61) | TUBB1CTSSCTSKMMP1MMP3 | |
| SCHEMBL6810366 | 0.89 | TUBB1 (0.65) | TUBB1MMP3MMP2 | |
| Hydrochloric Acid SCHEMBL6670866 | 0.89 | TUBB1 (0.60) | TUBB1CTSSCTSKMMP1MMP3 | |
| Hydrochloric Acid SCHEMBL6670873 | 0.89 | TUBB1 (0.60) | TUBB1CTSSCTSKMMP1MMP3 | |
| SCHEMBL6804951 | 0.88 | TUBB1 (0.64) | TUBB1CTSLCTSBCTSSCTSK | |
| SCHEMBL6804948 | 0.88 | TUBB1 (0.63) | TUBB1CTSKMMP1MMP3MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040121965-A1 | Method of treating resistant tumors | WYETH HOLDINGS CORPORATION (US) | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040121965-A1 | Method of treating resistant tumors | SLC11A2, VHL, REN | TUBB1 199/4885CTSL 2059/4885CTSB 756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.