Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.55 |
| ▸ | DRD3 | P35462 | 13/20 | 0.55 |
| ▸ | DRD4 | P21917 | 4/20 | 0.55 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5216341 | 1.00 | DRD2 (0.55) | DRD2DRD3DRD4RYR2CA1 | |
| SCHEMBL5220881 | 0.96 | DRD2 (0.52) | DRD2DRD3DRD4RYR2CA1 | |
| SCHEMBL6808015 | 0.91 | DRD2 (0.57) | DRD2DRD3DRD4CA1CA2 | |
| SCHEMBL5217360 | 0.91 | DRD2 (0.57) | DRD2DRD3DRD4CA1CA2 | |
| SCHEMBL5218886 | 0.90 | DRD2 (0.53) | DRD2DRD3DRD4CA1CA2 | |
| SCHEMBL5218975 | 0.90 | DRD2 (0.54) | DRD2DRD3DRD4CA1CA2 | |
| SCHEMBL5219121 | 0.90 | DRD2 (0.54) | DRD2DRD3DRD4CA1CA2 | |
| SCHEMBL6796054 | 0.89 | DRD2 (0.55) | DRD2DRD3DRD4CA1CA2 | |
| SCHEMBL5217173 | 0.89 | DRD2 (0.55) | DRD2DRD3DRD4CA1CA2 | |
| SCHEMBL6803033 | 0.88 | ALDH1A1 (0.44) | DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806278-B2 | SUCH AS (4-((6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YL)-PROPYL-AMINO) -PIPERIDIN-1-YL)(4-METHYL-PIPERAZIN-1-YL)-METHANONE; SMOOTH MUSCLE AND RESPIRATORY DISORDERS | SYNTEX (U.S.A.) LLC | 2004-10-19 | — | — | US | claimed |