Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6488009 | 0.79 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL6488000 | 0.78 | PTGS2 (0.40) | KMT2APTGS2PTGS1ALDH1A1HSD17B10 | |
| SCHEMBL6810546 | 0.75 | KMT2A (0.40) | KMT2APTGS2PTGS1ALDH1A1PARP1 | |
| SCHEMBL9559723 | 0.65 | BCL2L1 (0.42) | NPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL433264 | 0.65 | BCL2L1 (0.42) | NPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL27283535 | 0.63 | BCL2L1 (0.41) | NPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL28875378 | 0.63 | BCL2L1 (0.41) | NPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL27977995 | 0.61 | CYP11B1 (0.66) | KMT2APTGS2PTGS1ALDH1A1KDM4E | |
| SCHEMBL6290043 | 0.60 | PTGS2 (0.62) | KMT2APTGS2PTGS1ALDH1A1KDM4E | |
| SCHEMBL435275 | 0.59 | TTR (0.46) | KMT2AALDH1A1HSD17B10KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040122002-A1 | Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof | MERCKLE GMBH (DE) | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122002-A1 | Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof | PTGS1, PTGS2, PTGER1 | KMT2A 3737/4885PTGS2 2/4885PTGS1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.