Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6488000 | 0.81 | PTGS2 (0.40) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6808099 | 0.79 | KMT2A (0.40) | PTGS2PTGS1 | |
| SCHEMBL6485187 | 0.78 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL6476960 | 0.76 | PTGS2 (1.00) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6487417 | 0.76 | PTGS2 (0.62) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6477322 | 0.76 | PTGS2 (1.00) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6487001 | 0.74 | PTGS2 (0.60) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6724238 | 0.70 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL6476997 | 0.70 | PTGS2 (0.57) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6470141 | 0.69 | PTGS2 (0.74) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936632-B2 | Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof | MERCKLE GMBH (DE) | 2005-08-30 | — | — | US | disclosed |
| EP-1246825-B1 | FUSED PYRROLE COMPOUNDS, PHARMACEUTICAL AGENTS CONTAINING THE SAME, AND THE USE THEREOF | MERCKLE GMBH (DE) | 2003-12-17 | — | — | EP | disclosed |