Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.58 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.57 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.57 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.57 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.54 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11283688 | 0.88 | MAOB (0.60) | MAOBNR4A1NR4A2NR4A3PARP10 | |
| SCHEMBL6812863 | 0.86 | MAOB (0.61) | MAOBNR4A1NR4A2NR4A3PARP10 | |
| SCHEMBL27529019 | 0.85 | NR4A1 (0.62) | MAOBNR4A1NR4A2NR4A3PARP10 | |
| SCHEMBL103047 | 0.83 | MAOB (0.65) | MAOBNR4A1NR4A2NR4A3PARP10 | |
| SCHEMBL3395533 | 0.83 | NR4A1 (0.68) | MAOBNR4A1NR4A2NR4A3PARP10 | |
| SCHEMBL10799128 | 0.82 | TSHR (0.44) | NPC1RAB9AL3MBTL1ALDH1A1POLB | |
| SCHEMBL11751543 | 0.80 | NR4A2 (0.64) | MAOBNR4A1NR4A2NR4A3PARP10 | |
| SCHEMBL30285989 | 0.80 | PARP10 (0.65) | MAOBNR4A1NR4A2NR4A3PARP10 | |
| SCHEMBL6816962 | 0.80 | MAOB (0.69) | MAOBNR4A1NR4A2NR4A3PARP10 | |
| SCHEMBL514175 | 0.79 | ALDH1A1 (0.58) | PARP10SMN1; SMN2RAB9AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828513-B1 | COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS | PFIZER (US) | 2004-01-21 | — | — | EP | disclosed |
| EP-0777652-B1 | NEUROPROTECTIVE 3-(PIPERIDINYL-1)-CHROMAN-4,7-DIOL AND 1-(4-HYDROPHENYL)-2-(PIPERIDINYL-1)-ALKANOL DERIVATIVES | PFIZER (US) | 2003-06-25 | — | — | EP | disclosed |
| US-6258827-B1 | HYDROXYAROMATIC HETEROCYCLIC ALKANOLS AND LEVODOPA | PFIZER INC. | 2001-07-10 | — | — | US | disclosed |
| US-6046213-A | Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol derivatives | PFIZER INC. (US) | 2000-04-04 | — | — | US | disclosed |