Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CES2 | O00748 | 2/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 5/20 | 0.48 |
| ▸ | CA2 | P00918 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2097664 | 0.84 | ALDH1A1 (0.60) | ALDH1A1CYP1A2GSK3BCES2CES1 | |
| SCHEMBL10799128 | 0.82 | TSHR (0.44) | ALDH1A1CYP1A2CES2CES1MAPT | |
| SCHEMBL5060223 | 0.81 | ALDH1A1 (0.61) | ALDH1A1CYP1A2GSK3BCES2CES1 | |
| SCHEMBL4932919 | 0.81 | SLC6A2 (0.57) | ALDH1A1CYP1A2GSK3BCES2CES1 | |
| SCHEMBL25545681 | 0.81 | ALDH1A1 (0.57) | ALDH1A1CYP1A2GSK3BCES2CES1 | |
| SCHEMBL1108991 | 0.80 | ALDH1A1 (0.55) | ALDH1A1CYP1A2GSK3BCES2CES1 | |
| SCHEMBL3360353 | 0.80 | ALDH1A1 (0.68) | ALDH1A1CYP1A2GSK3BCES2CES1 | |
| SCHEMBL6808422 | 0.79 | MAOB (0.58) | ALDH1A1KMT2ALMNAMEN1RAB9A | |
| SCHEMBL1302941 | 0.79 | ALDH1A1 (0.54) | ALDH1A1CYP1A2GSK3BCES2CES1 | |
| SCHEMBL10918618 | 0.79 | TSHR (0.54) | ALDH1A1CYP1A2CA1CA2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102146026-B | Protosappanin A derivative and preparation method and application thereof | UNIV HARBIN MEDICAL | 2013-04-24 | — | — | CN | disclosed |
| US-20120029216-A1 | SCALABLE SYNTHETIC PROCESS FOR MAKING TERAMEPROCOL | ERIMOS PHARMACEUTICALS LLC (US) | 2012-02-02 | — | — | US | disclosed |
| CN-102171173-A | Scalable synthetic process for making meso-1,4 - bis (3,4 - dimethoxyphenyl)-dimethyl butane | ERIMOS PHARMACEUTICALS LLC | 2011-08-31 | — | — | CN | disclosed |
| CN-102146026-A | Protosappanin A derivative and preparation method and application thereof | UNIV HARBIN MEDICAL | 2011-08-10 | — | — | CN | disclosed |
| EP-2318347-A2 | SCALABLE SYNTHETIC PROCESS FOR MAKING TERAMEPROCOL | Erimos Pharmaceuticals LLC (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010014936-A2 | SCALABLE SYNTHETIC PROCESS FOR MAKING TERAMEPROCOL | ERIMOS PHARMACEUTICALS LLC (US) | 2010-02-04 | — | — | WO | disclosed |
| EP-0247035-B1 | OPTICALLY ACTIVE DL-NORDIHYDROGUAIARETIC ACID ISOMERS AND THEIR RACEMATES, PROCESS FOR PREPARING THEM AND METHOD OF IMPARTING A PLE | CHEMEX PHARMACEUTICALS, INC. (US) | 1990-01-24 | — | — | EP | disclosed |
| EP-0154887-B1 | NEW 2,5-DIARYL TETRAHYDROTHIOPHENES AND ANALOGS THEREOF AS PAF-ANTAGONISTS | MERCK & CO. INC. (US) | 1989-01-25 | — | — | EP | disclosed |
| US-4757084-A | Pharmaceuticals | MERCK & CO., INC. (US) | 1988-07-12 | — | — | US | disclosed |
| EP-0247035-A1 | Optically active dl-nordihydroguaiaretic acid isomers and their racemates, process for preparing them and method of imparting a ple. | CHEMEX PHARMACEUTICALS INC (US) | 1987-12-02 | — | — | EP | disclosed |
| EP-0070171-B1 | NOVEL PIPERIDINE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | KYOWA HAKKO KOGYO CO., LTD (JP) | 1986-10-15 | — | — | EP | disclosed |
| US-4595693-A | Method of use of 2,5-diaryl tetrahydrofurans and analogs thereof as PAF-antagonists | MERCK & CO., INC. (US) | 1986-06-17 | — | — | US | disclosed |
| US-4562298-A | Optically active nordihydroguaiaretic acid and intermediates | CHEMEX PHARMACEUTICALS, INC. (US) | 1985-12-31 | — | — | US | disclosed |
| EP-0154887-A1 | New 2,5-diaryl tetrahydrothiophenes and analogs thereof as paf-antagonists | MERCK & CO. INC. (US) | 1985-09-18 | — | — | EP | disclosed |
| EP-0029707-B1 | NOVEL PIPERIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1984-02-01 | — | — | EP | disclosed |
| US-4390536-A | HYPOTENSIVE AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1983-06-28 | — | — | US | disclosed |
| EP-0070171-A1 | Novel piperidine derivatives, processes for preparation thereof and pharmaceutical compositions containing same | KYOWA HAKKO KOGYO CO., LTD (JP) | 1983-01-19 | — | — | EP | disclosed |
| US-4344948-A | HYPOTENSIVE AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1982-08-17 | — | — | US | disclosed |
| US-4344945-A | HYPOTENSIVE AGENTS, BENZOXAZINYL DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1982-08-17 | — | — | US | disclosed |
| EP-0029707-A1 | Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1981-06-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120029216-A1 | SCALABLE SYNTHETIC PROCESS FOR MAKING TERAMEPROCOL | PTGIS, PTGES, POR | ALDH1A1 594/4885CYP1A2 46/4885GSK3B 3713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.