SCHEMBL6808475

SCHEMBL6808475

NC(=S)c1cccc2c1CCCC2=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 3/20 0.45
MAOA P21397 2/20 0.43
MAOB P27338 2/20 0.43
CYP2A6 P11509 1/20 0.43
MRGPRX4 Q96LA9 1/20 0.40
PARP1 P09874 1/20 0.38
ADRB2 P07550 1/20 0.38
ADRB1 P08588 1/20 0.38
HTR1A P08908 1/20 0.38
ADRB3 P13945 1/20 0.38
TSHR P16473 1/20 0.38
SLC6A4 P31645 1/20 0.38
SIGMAR1 Q99720 1/20 0.38
KDM4E B2RXH2 1/20 0.36
PRKCI P41743 1/20 0.35
ALOX15 P16050 1/20 0.35
MAPK1 P28482 1/20 0.35
CASP1 P29466 1/20 0.35
CASP7 P55210 1/20 0.35
HSD17B10 Q99714 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6812230 0.89 PARP1 (0.40) BRD4MAOAMAOBCYP2A6PARP1
SCHEMBL30853881 0.84 BRD4 (0.52) BRD4MAOAMAOBCYP2A6MRGPRX4
Hydrochloric Acid SCHEMBL6811509 0.81 BRD4 (0.44) BRD4MAOAMAOBCYP2A6MRGPRX4
SCHEMBL1759573 0.79 MRGPRX4 (0.51) BRD4MAOAMAOBCYP2A6MRGPRX4
SCHEMBL28041457 0.77 MAOA (0.56) BRD4MAOAMAOBCYP2A6MRGPRX4
Urea SCHEMBL6754151 0.76 BRD4 (0.48) BRD4MAOAMAOBCYP2A6MRGPRX4
SCHEMBL388480 0.74 PARP1 (0.53) BRD4MAOAMAOBCYP2A6MRGPRX4
SCHEMBL2768935 0.74 PARP1 (0.53) BRD4MAOAMAOBCYP2A6MRGPRX4
SCHEMBL5886388 0.73 PTPRC (0.48) MAOAMAOBCYP2A6MRGPRX4ADRB2
SCHEMBL21772776 0.73 PARP1 (0.51) BRD4MAOAMAOBCYP2A6MRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0808309-B1 IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS NOVARTIS AG (CH) 2004-10-06 EP disclosed
US-5840911-A ANTIPROTOZOA, ANTITUMOR NOVARTIS AG (CH) 1998-11-24 US disclosed
EP-0808309-A1 IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS Novartis AG (CH) 1997-11-26 EP disclosed
US-5639911-A Hydrazones CIBA-GEIGY CORPORATION (US) 1997-06-17 US disclosed
WO-1996022979-A1 IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS NOVARTIS AG (CH) 1996-08-01 WO disclosed
US-5461076-A Inhibitors of S-adenosylmethionine decarboxylase; antitumor agents NOVARTIS CORPORATION 1995-10-24 US disclosed
EP-0456133-B1 Hydrazones CIBA GEIGY AG (CH) 1995-03-15 EP disclosed
US-5395855-A Antitumor agents CIBA-GEIGY CORPORATION (US) 1995-03-07 US disclosed
EP-0538193-A2 Condensed cycloaliphatir-amidino-hydrazon salts as S-adenosylmethionin decarboxylase inhibitors CIBA-GEIGY AG (CH) 1993-04-21 EP disclosed
EP-0456133-A1 Hydrazones CIBA-GEIGY AG (CH) 1991-11-13 EP disclosed