Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970705 | 0.83 | TDP1 (0.44) | ADAMTS4MMP13MAOBTAAR1PARP10 | |
| SCHEMBL13929700 | 0.82 | NPC1 (0.47) | ADAMTS4MMP13MAOBTAAR1PARP10 | |
| SCHEMBL3970712 | 0.79 | RAB9A (0.47) | ADAMTS4MMP13MAOBNPC1TDP1 | |
| SCHEMBL6804913 | 0.78 | PARP10 (0.56) | MAOBPARP10MAPK1ALDH1A1MAPT | |
| SCHEMBL3968418 | 0.76 | TAAR1 (0.50) | MAOBTAAR1TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL3968416 | 0.76 | TAAR1 (0.42) | ADAMTS4MMP13MAOBTAAR1NPC1 | |
| SCHEMBL6628411 | 0.76 | NPC1 (0.52) | ADAMTS4MMP13MAOBPARP10NPC1 | |
| Hydrochloric Acid SCHEMBL6364077 | 0.75 | TAAR1 (0.49) | MAOBTAAR1TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL1758599 | 0.75 | TAAR1 (0.55) | TAAR1NPC1TDP1ALDH1A1MAPT | |
| SCHEMBL2089539 | 0.75 | MAOB (0.68) | MAOBL3MBTL1ALDH1A1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770647-B2 | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-03 | — | — | US | disclosed |
| WO-2003016248-A2 | BICYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-$G(A) CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY PATENT DEPARTMENT (US) | 2003-02-27 | — | — | WO | disclosed |