Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 6/20 | 0.44 |
| ▸ | TSPO | P30536 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | PTPRF | P10586 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6803823 | 0.86 | PARP10 (0.44) | PARP10MAOBMAOAALDH1A1MAPT | |
| SCHEMBL6805449 | 0.85 | PARP10 (0.67) | PARP10HDAC8MAOBMAOAALDH1A1 | |
| SCHEMBL6803571 | 0.84 | RAB9A (0.40) | PARP10HDAC8MAOBMAOASMN1; SMN2 | |
| SCHEMBL6809550 | 0.80 | MMP2 (0.46) | PARP10MAOBMAOAFFAR1FFAR4 | |
| SCHEMBL6804479 | 0.80 | MAOB (0.47) | MAOBMAOA | |
| SCHEMBL6804893 | 0.80 | SOD1 (0.42) | PARP10MAOBMAOAALDH1A1MAPT | |
| SCHEMBL6809153 | 0.78 | ADAMTS4 (0.42) | PARP10MAOBMAOAALDH1A1MAPT | |
| SCHEMBL6803414 | 0.78 | RAB9A (0.43) | MAOBFFAR1SMN1; SMN2 | |
| SCHEMBL6802634 | 0.78 | RAB9A (0.48) | MAOBMAOAFFAR1 | |
| SCHEMBL6804638 | 0.78 | GRM5 (0.41) | PARP10MAOBMAOAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770647-B2 | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-03 | — | — | US | disclosed |