Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 4/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | GPR6 | P46095 | 2/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6141349 | 0.94 | TAS2R14 (0.55) | TAS2R14CFTRTMPRSS4PTGDR2RXFP1 | |
| SCHEMBL22852812 | 0.87 | TAS2R14 (0.51) | TAS2R14CFTRTMPRSS4PTGDR2MRGPRX4 | |
| SCHEMBL6140921 | 0.86 | TAS2R14 (0.60) | TAS2R14TMPRSS4PTGDR2MRGPRX4MAP2K1 | |
| SCHEMBL6141098 | 0.81 | TAS2R14 (0.71) | TAS2R14MAP2K1RXFP1CDK2 | |
| SCHEMBL6141440 | 0.81 | TAS2R14 (0.71) | TAS2R14MAP2K1RXFP1CDK2 | |
| SCHEMBL22852807 | 0.78 | CFTR (0.45) | TAS2R14CFTRPTGDR2MRGPRX4RXFP1 | |
| SCHEMBL14055912 | 0.76 | NOTUM (0.47) | CFTRTMPRSS4MRGPRX4PDK1PDK2 | |
| SCHEMBL946193 | 0.76 | CYP1A2 (0.50) | PTGDR2MRGPRX4 | |
| SCHEMBL22853384 | 0.75 | GPR6 (0.42) | MRGPRX4MAP2K1GPR6PDK1PDK2 | |
| SCHEMBL30294720 | 0.75 | GPR6 (0.42) | MRGPRX4MAP2K1GPR6PDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040142993-A1 | Inhibitors of HCV NS5B polymerase | PHARMACIA & UPJOHN COMPANY | 2004-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142993-A1 | Inhibitors of HCV NS5B polymerase | POLRMT, POLR1E, CTDSP1 | TAS2R14 4336/4885CFTR 474/4885TMPRSS4 789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.