Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 8/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.55 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.55 |
| ▸ | CFD | P00746 | 1/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LIPC | P11150 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ASPH | Q12797 | 1/20 | 0.43 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.43 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6809409 | 0.93 | TAS2R14 (0.56) | TAS2R14AKR1B1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL6140781 | 0.91 | TAS2R14 (0.59) | TAS2R14AKR1B1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL6140963 | 0.88 | TAS2R14 (0.55) | TAS2R14AKR1B1AKR1C4AKR1C3AKR1C2 | |
| Hydrochloric Acid SCHEMBL6140941 | 0.85 | TAS2R14 (0.55) | TAS2R14AKR1B1AKR1C4AKR1C3AKR1C2 | |
| Hydrochloric Acid SCHEMBL6141263 | 0.85 | TAS2R14 (0.54) | TAS2R14AKR1B1AKR1C4AKR1C3AKR1C2 | |
| Hydrochloric Acid SCHEMBL6141251 | 0.85 | TAS2R14 (0.49) | TAS2R14AKR1B1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL6141255 | 0.84 | TAS2R14 (0.61) | TAS2R14AKR1B1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL6141209 | 0.84 | TAS2R14 (0.61) | TAS2R14AKR1B1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL6813056 | 0.84 | TAS2R14 (0.77) | TAS2R14AKR1B1AKR1C4AKR1C3AKR1C2 | |
| Hydrochloric Acid SCHEMBL6140912 | 0.84 | TAS2R14 (0.60) | TAS2R14AKR1B1AKR1C4AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040142993-A1 | Inhibitors of HCV NS5B polymerase | PHARMACIA & UPJOHN COMPANY | 2004-07-22 | — | — | US | claimed |
| US-20040142993-A1 | Inhibitors of HCV NS5B polymerase | PHARMACIA & UPJOHN COMPANY | 2004-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142993-A1 | Inhibitors of HCV NS5B polymerase | POLRMT, POLR1E, CTDSP1 | TAS2R14 4336/4885AKR1B1 2012/4885AKR1C4 2865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.