Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.40 |
| ▸ | CHRNG | P07510 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15189645 | 0.90 | CES2 (0.48) | CES2CES1RAB9ATSHRMAPT | |
| SCHEMBL6810006 | 0.88 | PIM1 (0.46) | RAB9ANPC1HTR7TSHRHDAC8 | |
| SCHEMBL7506850 | 0.84 | NPC1 (0.44) | RAB9ANPC1HTR7TSHRHDAC8 | |
| SCHEMBL25193546 | 0.83 | MEN1 (0.54) | CES2CES1RAB9AALDH1A1MEN1 | |
| SCHEMBL6814347 | 0.82 | NPC1 (0.67) | RAB9ANPC1HTR7TSHRHDAC8 | |
| SCHEMBL7389372 | 0.82 | CES2 (0.50) | CES2CES1RAB9ANPC1DRD2 | |
| SCHEMBL31073608 | 0.81 | HSD17B3 (0.60) | CES2CES1RAB9ANPC1HTR7 | |
| SCHEMBL31073614 | 0.81 | HSD17B3 (0.60) | CES2CES1RAB9ANPC1HTR7 | |
| SCHEMBL8742927 | 0.81 | NPC1 (0.65) | RAB9ANPC1HTR7TSHRHDAC8 | |
| SCHEMBL7505750 | 0.80 | PTPRC (0.43) | RAB9ANPC1TSHRMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040138287-A1 | Novel 5-phenyl-1h-indole derivatives as antagonists of interleukine-8 receptors | LABORATOIRES FOURNIER S.A. (FR) | 2004-07-15 | — | — | US | disclosed |
| US-6605633-B1 | Such as 5-Bromo-2-phenyl-1H-indole-3-butanoic acid | FOURNIER INDUSTRIE ET SANTE (FR) | 2003-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138287-A1 | Novel 5-phenyl-1h-indole derivatives as antagonists of interleukine-8 receptors | CXCL8, IL1RN, CCR8 | CES2 4174/4885CES1 2373/4885RAB9A 934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.