SCHEMBL6809938

SCHEMBL6809938

CC(Cl)C(N)(O)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 3/20 0.47
CYP1A2 P05177 3/20 0.47
KCNN4 O15554 2/20 0.42
ALDH1A1 P00352 2/20 0.40
CYP2C19 P33261 2/20 0.40
HSD17B10 Q99714 1/20 0.40
KMT2A Q03164 2/20 0.38
MAPT P10636 1/20 0.38
TSHR P16473 1/20 0.37
CRHBP P24387 1/20 0.37
CRHR2 Q13324 1/20 0.37
LMNA P02545 2/20 0.37
CHRM2 P08172 1/20 0.37
CHRM1 P11229 1/20 0.37
CHRM3 P20309 1/20 0.37
KCNH2 Q12809 1/20 0.37
KDM4E B2RXH2 2/20 0.36
MAPK1 P28482 1/20 0.36
CTDSP1 Q9GZU7 1/20 0.36
TAAR1 Q96RJ0 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27484323 0.82 CYP2D6 (0.50) CYP2D6CYP1A2KCNN4ALDH1A1CYP2C19
SCHEMBL28327278 0.82 CYP2D6 (0.55) CYP2D6CYP1A2KCNN4ALDH1A1CYP2C19
SCHEMBL9363854 0.82 CYP2D6 (0.55) CYP2D6CYP1A2KCNN4ALDH1A1CYP2C19
Hydrochloric Acid SCHEMBL28058934 0.80 CYP2D6 (0.53) CYP2D6CYP1A2KCNN4ALDH1A1CYP2C19
SCHEMBL13951979 0.80 CYP2D6 (0.48) CYP2D6CYP1A2KCNN4ALDH1A1CYP2C19
SCHEMBL6680720 0.77 ALDH1A1 (0.42) CYP2D6CYP1A2ALDH1A1CYP2C19HSD17B10
SCHEMBL28024684 0.77 CYP2D6 (0.46) CYP2D6CYP1A2KCNN4ALDH1A1CYP2C19
SCHEMBL15228150 0.73 KCNN4 (0.46) CYP2D6CYP1A2KCNN4ALDH1A1CYP2C19
SCHEMBL16539034 0.72 ADRA2C (0.42) CYP2D6CYP1A2KCNN4ALDH1A1CYP2C19
SCHEMBL4352236 0.72 MAPK1 (0.44) CYP2D6CYP1A2KCNN4ALDH1A1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1112275-B9 NOVEL HETEROAROMATIC INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE METABASIS THERAPEUTICS INC (US) 2004-03-10 EP disclosed
EP-1112275-B1 NOVEL HETEROAROMATIC INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE METABASIS THERAPEUTICS INC (US) 2003-07-30 EP disclosed
EP-1112275-A1 NOVEL HETEROAROMATIC INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE Metabasis Therapeutics, Inc. (US) 2001-07-04 EP disclosed
WO-2000014095-A1 NOVEL HETEROAROMATIC INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE METABASIS THERAPEUTICS, INC. (US) 2000-03-16 WO disclosed