Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6809969 | 0.87 | CYP1A2 (0.33) | CA12CA9CA1CA2CYP1A2 | |
| SCHEMBL6809964 | 0.74 | LMNA (0.31) | L3MBTL1MAPK1MEN1KMT2ATP53 | |
| SCHEMBL4443396 | 0.74 | TP53 (0.38) | CA12CA9CA2L3MBTL1MAPK1 | |
| SCHEMBL3970320 | 0.73 | MAPK1 (0.36) | L3MBTL1MAPK1MEN1KMT2AHTT | |
| SCHEMBL12960882 | 0.71 | HTT (0.41) | CA12CA9CA1CA2MAPK1 | |
| SCHEMBL4059736 | 0.68 | RXFP1 (0.39) | L3MBTL1MAPK1KMT2ATP53LMNA | |
| SCHEMBL3971807 | 0.68 | HDAC6 (0.45) | L3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL6460905 | 0.67 | MEN1 (0.45) | MEN1KMT2A | |
| SCHEMBL11995145 | 0.66 | CA2 (0.41) | CA12CA9CA1CA2CYP1A2 | |
| SCHEMBL3972121 | 0.65 | MAPK1 (0.37) | CA12CA9CA1CA2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770647-B2 | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-03 | — | — | US | disclosed |