Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.37 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17187572 | 1.00 | CYP1A2 (0.42) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| SCHEMBL4406677 | 0.85 | NOS2 (0.31) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| SCHEMBL19345089 | 0.80 | CYP1A2 (0.36) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| SCHEMBL7594974 | 0.79 | CYP2D6 (0.43) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| SCHEMBL2029661 | 0.79 | CYP2D6 (0.43) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| SCHEMBL2029987 | 0.79 | CYP2D6 (0.43) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| SCHEMBL5198224 | 0.79 | CYP2D6 (0.43) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| SCHEMBL2031639 | 0.79 | CYP2D6 (0.43) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| SCHEMBL7293342 | 0.79 | CYP2D6 (0.43) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 | |
| SCHEMBL5198220 | 0.79 | CYP2D6 (0.43) | CYP1A2ALOX15CYP2C19CYP2D6SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6833489-B1 | Comprises the steps of introducing a test compound into a test chimeric, Prolyl-4-hydroxylase (P4H)-gene modified, or a wild-type nematode, wherein the test chimeric nematode has a complemented prolyl-4- hydroxylase gene mutation | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2004-12-21 | — | — | US | disclosed |