Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 4/20 | 0.54 |
| ▸ | AURKA | O14965 | 3/20 | 0.54 |
| ▸ | PARP1 | P09874 | 14/20 | 0.53 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.53 |
| ▸ | PKN1 | Q16512 | 3/20 | 0.52 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
| ▸ | CLK2 | P49760 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6801983 | 0.91 | AURKB (0.68) | AURKBAURKAPARP1PARP2PKN1 | |
| SCHEMBL6805985 | 0.89 | PARP1 (0.56) | AURKBAURKAPARP1PARP2PKN1 | |
| SCHEMBL6805695 | 0.88 | AURKB (0.66) | AURKBAURKAPARP1PARP2PKN1 | |
| SCHEMBL6589131 | 0.86 | AURKB (0.40) | AURKBAURKAPARP1PARP2PKN1 | |
| SCHEMBL6810109 | 0.85 | AURKA (0.40) | AURKBAURKAPARP1PARP2PLK4 | |
| SCHEMBL3582276 | 0.79 | AURKB (0.82) | AURKBAURKAPARP1PARP2KDR | |
| SCHEMBL6805085 | 0.78 | AURKA (0.83) | AURKBAURKAPARP1KDRDHODH | |
| SCHEMBL6590870 | 0.78 | AURKB (0.51) | AURKBAURKAPARP1PRKD3PIM1 | |
| SCHEMBL6801999 | 0.77 | AURKB (0.50) | AURKBAURKAPARP1PARP2PRKD3 | |
| SCHEMBL6810111 | 0.76 | PARP1 (0.57) | AURKBAURKAPARP1PARP2PKN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |