Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 5/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.37 |
| ▸ | ATR | Q13535 | 2/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6801999 | 0.92 | AURKB (0.50) | AURKAAURKBPARP1PARP2KDR | |
| SCHEMBL6805989 | 0.89 | PARP1 (0.38) | AURKAAURKBPARP1PARP2KDR | |
| SCHEMBL6805702 | 0.88 | AURKA (0.48) | AURKAAURKBPARP1KDR | |
| SCHEMBL6810101 | 0.85 | AURKB (0.54) | AURKAAURKBPARP1PARP2KDR | |
| SCHEMBL3582282 | 0.79 | AURKB (0.61) | AURKAAURKBPARP1ACHENR4A1 | |
| SCHEMBL6801983 | 0.78 | AURKB (0.68) | AURKAAURKBPARP1PARP2KDR | |
| SCHEMBL6805101 | 0.78 | AURKA (0.64) | AURKAAURKBPARP1ACHEKDR | |
| SCHEMBL6810121 | 0.77 | HTR1A (0.41) | AURKBPARP1KDRCLK4 | |
| SCHEMBL6806267 | 0.76 | HTR1A (0.43) | AURKAAURKBPARP1KDRCSF1R | |
| SCHEMBL3582849 | 0.76 | AURKB (0.58) | AURKAAURKBPARP1ACHENR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |