Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.46 |
| ▸ | PARP1 | P09874 | 8/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.43 |
| ▸ | DHODH | Q02127 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6810134 | 0.82 | PARP1 (0.65) | CHEK2PARP1KDRPARP2DHODH | |
| SCHEMBL6810729 | 0.80 | PI4K2A (0.47) | NPC1POLBRAB9AMCL1CHEK2 | |
| SCHEMBL3585144 | 0.79 | PARP1 (0.64) | NPC1POLBRAB9APARP1DHODH | |
| SCHEMBL2149454 | 0.78 | PARP1 (0.63) | CHEK2PARP1PARP2DHODHDYRK1A | |
| SCHEMBL6809996 | 0.78 | PKN1 (0.63) | CHEK2PARP1PARP2DHODHDYRK1A | |
| SCHEMBL3579908 | 0.78 | PARP1 (0.61) | NPC1RAB9ACHEK2PARP1PARP2 | |
| SCHEMBL29696369 | 0.78 | NPC1 (0.53) | NPC1RAB9APARP1DHODHMAPK14 | |
| SCHEMBL6806964 | 0.78 | PKN1 (0.65) | NPC1RAB9ACHEK2PARP1PARP2 | |
| SCHEMBL31032103 | 0.77 | NPC1 (0.57) | NPC1POLBRAB9AMCL1PARP1 | |
| SCHEMBL16970998 | 0.76 | PARP1 (0.41) | PARP1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |