Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.64 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579908 | 0.86 | PARP1 (0.61) | PARP1NPC1HPGDRAB9AKDM4E | |
| SCHEMBL29696369 | 0.85 | NPC1 (0.53) | PARP1NPC1RAB9ADHODH | |
| SCHEMBL31053400 | 0.82 | PARP1 (0.67) | PARP1MAP4K4PIM1AURKBHIPK2 | |
| SCHEMBL7136552 | 0.81 | PARP1 (0.52) | PARP1PIM1AURKBDHODH | |
| SCHEMBL6809996 | 0.81 | PKN1 (0.63) | PARP1HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL2149454 | 0.81 | PARP1 (0.63) | PARP1PLK4MAP4K4PIM1AURKB | |
| SCHEMBL6806964 | 0.80 | PKN1 (0.65) | PARP1NPC1HPGDRAB9AKDM4E | |
| SCHEMBL3582864 | 0.80 | GRK6 (0.48) | PARP1TP53HTT | |
| SCHEMBL28671805 | 0.80 | NPC1 (0.65) | PARP1NPC1HPGDRAB9ATP53 | |
| SCHEMBL6810137 | 0.79 | NPC1 (0.47) | PARP1NPC1RAB9APOLBPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |