Niacinamide

Niacinamide

SCHEMBL6811151

NC(=O)c1cccnc1.O=C[C@H](O)[C@H](O)[C@H](O)COP(=O)(O)O

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SIRT2 Q8IXJ6 2/20 0.49
SIRT1 Q96EB6 2/20 0.49
SIRT3 Q9NTG7 2/20 0.49
F7 P08709 1/20 0.49
F3 P13726 1/20 0.49
SARM1 Q6SZW1 1/20 0.49
SIRT6 Q8N6T7 1/20 0.49
SIRT5 Q9NXA8 1/20 0.49
SIRT4 Q9Y6E7 1/20 0.49
MPI P34949 1/20 0.45
PGD P52209 1/20 0.38
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
LMNA P02545 1/20 0.36
MKNK1 Q9BUB5 1/20 0.36
MKNK2 Q9HBH9 1/20 0.36
THRB P10828 1/20 0.36
HDAC1 Q13547 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Niacinamide SCHEMBL5674257 0.89 F7 (0.45) SIRT2SIRT1SIRT3F7F3
Xylose SCHEMBL4484244 0.86 SIRT2 (0.48) SIRT2SIRT1SIRT3F7F3
Xylose SCHEMBL23706155 0.85 F7 (0.52) SIRT2SIRT1SIRT3F7F3
Xylose SCHEMBL938610 0.82 F7 (0.58) SIRT2SIRT1SIRT3F7F3
Xylose SCHEMBL23925306 0.82 F7 (0.58) SIRT2SIRT1SIRT3F7F3
Xylose SCHEMBL20423632 0.81 F7 (0.56) SIRT2SIRT1SIRT3F7F3
Xylose SCHEMBL28724079 0.81 F7 (0.56) SIRT2SIRT1SIRT3F7F3
Xylose SCHEMBL28364957 0.79 F7 (0.43) SIRT2SIRT1SIRT3F7F3
Demannose SCHEMBL27666893 0.79 F7 (0.56) SIRT2SIRT1SIRT3F7F3
Cadaverine Tartrate SCHEMBL28825318 0.77 F7 (0.51) SIRT2SIRT1SIRT3F7F3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020182600-A1 Method for assaying biological and other constituents using synthetic nucleounits in lateral flow, liquid, and dry chemistry techniques SMITH JACK V (US) 2002-12-05 US claimed
WO-2023212104-A1 METHODS AND AGENTS FOR PREVENTING SKELETAL AGING, OSTEOPOROSIS AND OBESITY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-11-02 WO disclosed
US-11168106-B1 Synthesis and stabilization of nicotinamide ribose and its derivatives KIM HYO JOONG (US) 2021-11-09 US disclosed
US-11168106-B1 Synthesis and stabilization of nicotinamide ribose and its derivatives KIM HYO JOONG (US) 2021-11-09 US disclosed
EP-3401323-B1 NICOTINAMIDE MONONUCLEOTIDE DERIVATIVE AND SALT THEREOF, METHOD FOR PRODUCING THE SAME, TOPICAL AGENT, COSMETIC AND FOOD ADDITIVE SHOWA DENKO KK (JP) 2020-07-08 EP disclosed
US-20040121420-A1 Method for detection of 4-hydroxybutyric acid and its precursor(s) in fluids SMITH JACK V (US) 2004-06-24 US disclosed
US-6617123-B1 Contacting sample with mixture of an esterase, a pH indicator dye and a buffer; colorimetric analysis; easy, convenient test strips SMITH JACK V (US) 2003-09-09 US disclosed
US-20030073219-A1 Crystal structure ASTEX TECHNOLOGY LIMITED (GB) 2003-04-17 US disclosed
US-20020182600-A1 Method for assaying biological and other constituents using synthetic nucleounits in lateral flow, liquid, and dry chemistry techniques SMITH JACK V (US) 2002-12-05 US disclosed
US-20010019821-A1 Method for manufacturing and detecting and normalizing HIV for rapid analysis SMITH JACK V (US) 2001-09-06 US disclosed