Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.48 |
| ▸ | F7 | P08709 | 1/20 | 0.48 |
| ▸ | F3 | P13726 | 1/20 | 0.48 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.48 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Xylose SCHEMBL23706155 | 0.93 | F7 (0.52) | SIRT2SIRT1SIRT3F7F3 | |
| Xylose SCHEMBL23925306 | 0.91 | F7 (0.58) | SIRT2SIRT1SIRT3F7F3 | |
| Xylose SCHEMBL938610 | 0.91 | F7 (0.58) | SIRT2SIRT1SIRT3F7F3 | |
| Xylose SCHEMBL20423632 | 0.90 | F7 (0.56) | SIRT2SIRT1SIRT3F7F3 | |
| Xylose SCHEMBL28724079 | 0.90 | F7 (0.56) | SIRT2SIRT1SIRT3F7F3 | |
| Demannose SCHEMBL27666893 | 0.87 | F7 (0.56) | SIRT2SIRT1SIRT3F7F3 | |
| Xylose SCHEMBL28364957 | 0.87 | F7 (0.43) | SIRT2SIRT1SIRT3F7F3 | |
| Niacinamide SCHEMBL6811151 | 0.86 | SIRT2 (0.49) | SIRT2SIRT1SIRT3F7F3 | |
| Cadaverine Tartrate SCHEMBL28825318 | 0.85 | F7 (0.51) | SIRT2SIRT1SIRT3F7F3 | |
| Xylose SCHEMBL28825332 | 0.85 | F7 (0.51) | SIRT2SIRT1SIRT3F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504489-B2 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2009-03-17 | — | — | US | disclosed |
| US-7056894-B2 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2006-06-06 | — | — | US | disclosed |
| US-20060084616-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. | 2006-04-20 | — | — | US | disclosed |
| EP-1370139-A2 | INHIBITORS OF ADP-RIBOSYL TRANSFERASES, CYCLASES, AND HYDROLASES, AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2003-12-17 | — | — | EP | disclosed |
| US-20020132783-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. | 2002-09-19 | — | — | US | disclosed |
| WO-2002059084-A2 | INHIBITORS OF ADP-RIBOSYL TRANSFERASES, CYCLASES, AND HYDROLASES, AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020132783-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | CD38, ADPRS, NTPCR | SIRT2 731/4885SIRT1 285/4885SIRT3 517/4885 |
| US-20060084616-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | CD38, ADPRS, NTPCR | SIRT2 692/4885SIRT1 261/4885SIRT3 493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.