Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6811402 | 1.00 | MAPT (0.67) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL6811797 | 0.87 | MAPT (0.64) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL6811795 | 0.87 | MAPT (0.64) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL6811992 | 0.82 | MAPT (0.77) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL6811998 | 0.82 | MAPT (0.77) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL7858387 | 0.80 | MAPT (1.00) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL6811781 | 0.74 | TLR9 (0.46) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL6812618 | 0.72 | MAPT (0.94) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL6812622 | 0.72 | MAPT (0.94) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL8898616 | 0.69 | L3MBTL1 (0.46) | MAPTALDH1A1MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808309-B1 | IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS | NOVARTIS AG (CH) | 2004-10-06 | — | — | EP | disclosed |
| US-5840911-A | ANTIPROTOZOA, ANTITUMOR | NOVARTIS AG (CH) | 1998-11-24 | — | — | US | disclosed |