Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6811797 | 1.00 | MAPT (0.64) | MAPTTAAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL6811402 | 0.87 | MAPT (0.67) | MAPTTAAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL6811399 | 0.87 | MAPT (0.67) | MAPTTAAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL7858387 | 0.78 | MAPT (1.00) | MAPTTAAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL6811992 | 0.77 | MAPT (0.77) | MAPTTAAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL6811998 | 0.77 | MAPT (0.77) | MAPTTAAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL6812622 | 0.76 | MAPT (0.94) | MAPTTAAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL6812618 | 0.76 | MAPT (0.94) | MAPTTAAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL6812347 | 0.75 | MAPT (0.82) | MAPTTAAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL6812342 | 0.75 | MAPT (0.82) | MAPTTAAR1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808309-B1 | IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS | NOVARTIS AG (CH) | 2004-10-06 | — | — | EP | disclosed |
| US-5840911-A | ANTIPROTOZOA, ANTITUMOR | NOVARTIS AG (CH) | 1998-11-24 | — | — | US | disclosed |
| EP-0808309-A1 | IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS | Novartis AG (CH) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996022979-A1 | IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS | NOVARTIS AG (CH) | 1996-08-01 | — | — | WO | disclosed |