Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 7/20 | 0.41 |
| ▸ | PDE2A | O00408 | 8/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 3/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681241 | 0.90 | PDE2A (0.43) | EPHX2PDE2AMAPK1AKT1AKT2 | |
| SCHEMBL17803805 | 0.89 | MAPK1 (0.43) | MAPK1AKT1AKT2AKT3 | |
| SCHEMBL12188501 | 0.88 | EPHX2 (0.44) | EPHX2PDE2AMAPK1AKT1AKT2 | |
| SCHEMBL2738631 | 0.86 | EPHX2 (0.44) | EPHX2PDE2AMAPK1AKT1AKT2 | |
| SCHEMBL681588 | 0.85 | MAPK1 (0.39) | EPHX2PDE2AMAPK1AKT1AKT2 | |
| SCHEMBL681766 | 0.85 | CTSS (0.41) | EPHX2 | |
| SCHEMBL17803804 | 0.83 | ALDH1A1 (0.40) | MAPK1AKT1AKT2AKT3 | |
| SCHEMBL681770 | 0.83 | AKT1 (0.40) | MAPK1IDH1AKT1AKT2AKT3 | |
| SCHEMBL681179 | 0.83 | AKT1 (0.51) | MAPK1AKT1AKT2AKT3 | |
| SCHEMBL12194528 | 0.83 | AKT1 (0.40) | MAPK1IDH1AKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |