Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 16/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679737 | 0.88 | PDE2A (0.49) | PDE2ASLC6A4SLC6A2SLC6A3GAA | |
| SCHEMBL684209 | 0.86 | PDE2A (0.50) | PDE2ASLC6A4SLC6A2SLC6A3GAA | |
| SCHEMBL8223539 | 0.85 | PDE2A (0.49) | PDE2ASLC6A4SLC6A2SLC6A3GAA | |
| SCHEMBL17803814 | 0.83 | KDM4E (0.32) | SLC6A2 | |
| SCHEMBL681790 | 0.82 | PDE2A (0.54) | PDE2ASLC6A4 | |
| SCHEMBL681584 | 0.79 | PDE2A (0.50) | PDE2ASLC6A4 | |
| SCHEMBL681254 | 0.74 | PDE2A (0.45) | PDE2ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL681320 | 0.71 | PDE2A (0.54) | PDE2ASLC6A4GAA | |
| SCHEMBL681781 | 0.71 | PDE2A (0.42) | PDE2ASLC6A4SLC6A2SLC6A3GAA | |
| SCHEMBL12168589 | 0.70 | KDM4E (0.34) | SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |