Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 14/20 | 0.54 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681320 | 0.86 | PDE2A (0.54) | PDE2AIDO1SLC6A4GPR139PNMT | |
| SCHEMBL12188449 | 0.83 | PDE2A (0.54) | PDE2AIDO1GPR139PNMT | |
| SCHEMBL681584 | 0.83 | PDE2A (0.50) | PDE2ASLC6A4GPR139 | |
| SCHEMBL681205 | 0.82 | PDE2A (0.49) | PDE2ASLC6A4 | |
| SCHEMBL2738655 | 0.81 | PDE2A (0.51) | PDE2AIDO1GPR139PNMT | |
| SCHEMBL17803817 | 0.81 | ADRA1A (0.35) | GPR139 | |
| SCHEMBL681363 | 0.80 | KCNH2 (0.38) | — | |
| SCHEMBL680198 | 0.80 | APLNR (0.44) | — | |
| SCHEMBL681254 | 0.78 | PDE2A (0.45) | PDE2ASLC6A4 | |
| SCHEMBL18636315 | 0.77 | PDE2A (0.60) | PDE2AIDO1PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |