Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 14/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681232 | 0.87 | PDE2A (0.50) | PDE2AADRB2ADRB1ADRB3GPR139 | |
| SCHEMBL12188384 | 0.86 | PDE2A (0.51) | PDE2AADRB2ADRB1ADRB3GPR139 | |
| SCHEMBL2738439 | 0.85 | PDE2A (0.50) | PDE2AADRB2ADRB1ADRB3GPR139 | |
| SCHEMBL681790 | 0.83 | PDE2A (0.54) | PDE2AGPR139SLC6A4 | |
| SCHEMBL17803802 | 0.83 | ADRB2 (0.41) | ADRB2ADRB1ADRB3GPR139 | |
| SCHEMBL681254 | 0.82 | PDE2A (0.45) | PDE2ASLC6A4 | |
| SCHEMBL681752 | 0.82 | ADRB2 (0.40) | ADRB2ADRB1ADRB3 | |
| SCHEMBL681362 | 0.82 | ADRB2 (0.40) | ADRB2ADRB1ADRB3 | |
| SCHEMBL681744 | 0.82 | ADRB2 (0.40) | ADRB2ADRB1ADRB3 | |
| SCHEMBL681594 | 0.80 | CA1 (0.38) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |