Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681430 | 0.88 | MAPK1 (0.42) | AKT1MAPK1EPHX1SLC22A3NOTUM | |
| SCHEMBL12188435 | 0.87 | AKT1 (0.42) | AKT1MAPK1EPHX1SLC22A3NOTUM | |
| SCHEMBL681741 | 0.87 | KCNN4 (0.37) | SLC22A3EPHX2 | |
| SCHEMBL8226056 | 0.86 | AKT1 (0.46) | AKT1MAPK1EPHX1SLC22A3NOTUM | |
| SCHEMBL681325 | 0.85 | PDE2A (0.47) | EPHX2 | |
| SCHEMBL681158 | 0.82 | AKT1 (0.46) | AKT1AKR1C3AKR1C2RPS6KB1 | |
| SCHEMBL681719 | 0.81 | ALDH1A1 (0.44) | MAPK1ALDH1A1 | |
| SCHEMBL681539 | 0.80 | AKT1 (0.44) | AKT1MAPK1RPS6KB1ALDH1A1 | |
| SCHEMBL681191 | 0.80 | AKT1 (0.44) | AKT1MAPK1RPS6KB1ALDH1A1 | |
| SCHEMBL681686 | 0.80 | ALDH1A1 (0.43) | EPHX1EPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |