SCHEMBL6812896

SCHEMBL6812896

COc1ccccc1-c1cn(N)c(N)n1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 2/20 0.58
ALDH1A1 P00352 6/20 0.53
KDM4E B2RXH2 3/20 0.53
MAPT P10636 2/20 0.53
PKM P14618 1/20 0.53
ADORA2A P29274 3/20 0.52
HSP90AA1 P07900 2/20 0.51
HSP90AB1 P08238 1/20 0.50
GAA P10253 3/20 0.45
LMNA P02545 1/20 0.45
JAK2 O60674 1/20 0.44
METAP2 P50579 1/20 0.44
DPP4 P27487 1/20 0.43
HPGD P15428 1/20 0.43
ALOX15 P16050 1/20 0.43
ALOX12 P18054 1/20 0.43
HSD17B10 Q99714 1/20 0.43
PTPN1 P18031 1/20 0.43
POLB P06746 1/20 0.43
ATP4A P20648 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6811781 0.80 TLR9 (0.46) TLR8ALDH1A1KDM4EMAPTPKM
Hydrochloric Acid SCHEMBL1666051 0.76 TLR8 (0.66) TLR8ADORA2AHSP90AA1HSP90AB1DPP4
SCHEMBL6811797 0.74 MAPT (0.64) TLR8ALDH1A1KDM4EMAPTADORA2A
SCHEMBL6811795 0.74 MAPT (0.64) TLR8ALDH1A1KDM4EMAPTADORA2A
SCHEMBL21690179 0.72 HDAC3 (0.47) TLR8ALDH1A1KDM4EADORA2AHSP90AA1
SCHEMBL27374278 0.72 KDM4E (0.50) ALDH1A1KDM4EMAPTADORA2AHSP90AA1
SCHEMBL25216599 0.72 SUV39H2 (0.65) TLR8ADORA2AHSP90AA1HSP90AB1JAK2
SCHEMBL3364095 0.71 HSP90AA1 (0.55) ALDH1A1KDM4EMAPTADORA2AHSP90AA1
SCHEMBL3629826 0.71 ALDH1A1 (0.57) ALDH1A1KDM4EMAPTPKMHSP90AA1
SCHEMBL234658 0.70 ALDH1A1 (0.63) ALDH1A1KDM4EMAPTHSP90AA1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0808309-B1 IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS NOVARTIS AG (CH) 2004-10-06 EP disclosed
US-5840911-A ANTIPROTOZOA, ANTITUMOR NOVARTIS AG (CH) 1998-11-24 US disclosed
EP-0808309-A1 IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS Novartis AG (CH) 1997-11-26 EP disclosed
WO-1996022979-A1 IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS NOVARTIS AG (CH) 1996-08-01 WO disclosed