Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | NOS3 | P29474 | 1/20 | 0.55 |
| ▸ | NOS1 | P29475 | 1/20 | 0.55 |
| ▸ | NOS2 | P35228 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.54 |
| ▸ | CYP2A13 | Q16696 | 3/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15467001 | 0.88 | HRH3 (0.87) | HRH3SMN1; SMN2NOS3NOS1NOS2 | |
| Bromide SCHEMBL7067746 | 0.82 | HRH3 (0.71) | HRH3SMN1; SMN2ALDH1A1NCF1 | |
| Bromide SCHEMBL27778714 | 0.81 | HRH3 (0.69) | HRH3SMN1; SMN2NOS3NOS1NOS2 | |
| 4-(4-Chlorobenzyl)Morpholine SCHEMBL4103722 | 0.80 | HRH3 (0.74) | HRH3SMN1; SMN2ALDH1A1LMNAMAPT | |
| Bromide SCHEMBL6813702 | 0.80 | HRH3 (0.75) | HRH3SMN1; SMN2ALDH1A1NCF1 | |
| SCHEMBL13362301 | 0.80 | HRH3 (0.74) | HRH3SMN1; SMN2NOS3NOS1NOS2 | |
| Bromide SCHEMBL6818242 | 0.79 | NCF1 (0.64) | HRH3SMN1; SMN2NOS1ALDH1A1CYP2A13 | |
| SCHEMBL19068966 | 0.78 | HRH3 (0.71) | HRH3SMN1; SMN2NOS3NOS1NOS2 | |
| SCHEMBL254624 | 0.78 | HIF1A (0.73) | HRH3SMN1; SMN2NOS3NOS1NOS2 | |
| SCHEMBL22711526 | 0.78 | HRH3 (0.71) | HRH3SMN1; SMN2NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224364-A1 | Organo-zinc compounds | RIEKE METALS, INC. | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224364-A1 | Organo-zinc compounds | ZFX, CXXC5, CXXC4 | HRH3 2675/4885SMN1; SMN2 3620/4885NOS3 2867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.