CXXC4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL19054826	0.44	8/20
SCHEMBL2701157	0.69	5/20
SCHEMBL2701160	0.69	5/20
Acrylamide (SCHEMBL3714624)	0.42	5/20
Acrylamide (SCHEMBL8498177)	0.42	5/20
SCHEMBL14520965	0.72	4/20
SCHEMBL2526026	0.64	4/20
SCHEMBL2529201	0.57	4/20
SCHEMBL2526312	0.55	4/20
Hydrochloric Acid (SCHEMBL2529676)	0.54	4/20
SCHEMBL12216179	0.54	4/20
SCHEMBL12018334	0.53	4/20
SCHEMBL12195116	0.52	4/20
SCHEMBL3790649	0.51	4/20
SCHEMBL12987884	0.49	4/20
SCHEMBL12987813	0.49	4/20
SCHEMBL167151	0.47	4/20
SCHEMBL12764449	0.47	4/20
SCHEMBL12988312	0.46	4/20
SCHEMBL3909752	0.45	4/20

Clinical trials — most relevant to CXXC4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer	PHASE1/PHASE2	SUSPENDED
Safety and Dose Escalation Study of Zinc Supplementation in Critically Ill Children	PHASE1/PHASE2	COMPLETED
Study of the Beach Regimen on Relapsed/Refractory Acute Myeloid Leukemia (R/R AML)	PHASE2	ACTIVE_NOT_RECRUITING
Peptide Vaccinations to Treat Patients With Low-Risk Myeloid Cancers	PHASE2	COMPLETED
Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft TIssue Sarcoma After Pre-treatment Failure	PHASE2	COMPLETED
SCARFREE-001: Verteporfin for Scar Prevention	PHASE2	NOT_YET_RECRUITING
A Phase I Study of 5-Azacytidine in Combination With Chemotherapy for Children With Relapsed or Refractory ALL or AML	PHASE1	COMPLETED
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
C-X-C Chemokine Receptor 4 in Chronic Lymphocytic Leukemia	nan	UNKNOWN
Analysis of the Role of AIRE in Autoimmune Neurological Diseases Associated With Autoantibodies	nan	RECRUITING
Genetic Clues to Chordoma Etiology: A Protocol to Identify Sporadic Chordoma Patients for Studies of Cancer-Susceptibility Genes	nan	ACTIVE_NOT_RECRUITING
Amplification of Zinc Finger Protein 217 Gene in Multiple Myeloma	nan	UNKNOWN
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea	nan	RECRUITING
Study of the Sex Differences in Inflammatory Diseases in Children	nan	UNKNOWN
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
NCF Gene & TNFSF4 in SLE Patients	nan	UNKNOWN
Immunophenotyping and Xist Gene in AML	nan	UNKNOWN
Zinc and the Synthesis of Zinc Binding Proteins (Protocol B)	nan	COMPLETED
X-chromosome Inactivation, Epigenetics and the Transcriptome	nan	COMPLETED
Gene Expression Variation and Implant Wound Healing Among Smokers and Diabetics	nan	COMPLETED
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia	nan	UNKNOWN
Linkage Study in Familial Pulmonary Fibrosis	nan	COMPLETED
Detection of IKZF1 Deletion Mutation in Patients With Acute Lymphoblastic Leukemia and Its Impact in Therapy	nan	UNKNOWN
Genetic Aspects of Chordoma: A Collaboration With SEER Registries to Identify Chordoma Families	nan	COMPLETED
Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome	nan	COMPLETED
CIQTP Prolongation : Role and Mechanism in Sudden Cardiac Death	nan	COMPLETED
Study of Tazemetostat in Adults With Follicular Lymphoma Previously Treated With at Least Two Therapies	nan	WITHDRAWN
EPIgenetics and in Vivo Resistance of Chronic Myeloid Leukemia Stem Cells to Tyrosine Kinase Inhibitors	nan	UNKNOWN
The Etiology and Progression of Brain Tumors	nan	COMPLETED
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CXXC4 binder may also engage these)

Protein	Name	Similarity
Q9EQC9	—	1.000	Q9EQC9 →
Q0VFP6	—	1.000	Q0VFP6 →
Q6NXI8	—	1.000	Q6NXI8 →
Q800L6	—	0.994	Q800L6 →
P0DH66	—	0.990	P0DH66 →
Q90655	—	0.989	Q90655 →
Q80WT2	—	0.989	Q80WT2 →
P70284	—	0.989	P70284 →
Q32LB3	—	0.989	Q32LB3 →
Q9SEZ1	—	0.989	Q9SEZ1 →
P19091	—	0.988	P19091 →
Q8IYA7	—	0.988	Q8IYA7 →
Q63449	—	0.988	Q63449 →
Q80X32	—	0.988	Q80X32 →
P46200	—	0.988	P46200 →
Q63ZH2	—	0.987	Q63ZH2 →
Q949U2	—	0.987	Q949U2 →
Q90ZS6	—	0.987	Q90ZS6 →
Q92858	—	0.987	Q92858 →
Q64163	—	0.987	Q64163 →
Q9SV15	—	0.987	Q9SV15 →
Q7Z6R9	—	0.987	Q7Z6R9 →
Q08727	—	0.987	Q08727 →
Q8VZS3	—	0.987	Q8VZS3 →
Q6YHU8	—	0.987	Q6YHU8 →
P24899	—	0.987	P24899 →
O04609	—	0.987	O04609 →
Q753Y2	—	0.987	Q753Y2 →
P33400	—	0.987	P33400 →
P06537	—	0.987	P06537 →