Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 16/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679735 | 0.87 | LMNA (0.40) | LMNAGPR139HPGD | |
| SCHEMBL681191 | 0.85 | AKT1 (0.44) | LMNAGPR139HPGD | |
| SCHEMBL681539 | 0.85 | AKT1 (0.44) | LMNAGPR139HPGD | |
| SCHEMBL684434 | 0.85 | LMNA (0.41) | LMNAGPR139HPGD | |
| SCHEMBL680165 | 0.85 | AKT1 (0.36) | GPR139 | |
| SCHEMBL2738672 | 0.84 | LMNA (0.40) | LMNAGPR139HPGD | |
| SCHEMBL680134 | 0.83 | EPHX1 (0.38) | — | |
| SCHEMBL680152 | 0.81 | APP (0.38) | GPR139 | |
| SCHEMBL681699 | 0.79 | AKT1 (0.41) | LMNA | |
| SCHEMBL681179 | 0.77 | AKT1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |