Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOL1 | O14791 | 1/20 | 0.56 |
| ▸ | CXCR2 | P25025 | 12/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22118342 | 0.89 | APOL1 (0.66) | APOL1CXCR2MTNR1AMTNR1BPPARG | |
| SCHEMBL6810442 | 0.86 | CXCR2 (0.55) | CXCR2PPARGCYP2C9 | |
| SCHEMBL6809596 | 0.83 | CXCR2 (0.54) | CXCR2PPARGCYP2C9 | |
| SCHEMBL22118414 | 0.81 | APOL1 (0.68) | APOL1CXCR2MTNR1AMTNR1BPPARG | |
| SCHEMBL6805881 | 0.81 | CXCR2 (0.52) | CXCR2PPARGCYP2C9 | |
| SCHEMBL6810068 | 0.81 | CXCR2 (0.55) | CXCR2PPARGCYP2C9 | |
| SCHEMBL6810453 | 0.81 | CXCR2 (0.53) | CXCR2PPARGCYP2C9 | |
| SCHEMBL6810265 | 0.80 | CXCR2 (0.56) | CXCR2PPARGCYP2C9 | |
| SCHEMBL6810400 | 0.80 | CXCR2 (0.51) | CXCR2PPARGCYP2C9 | |
| SCHEMBL7241810 | 0.79 | CXCR2 (0.56) | CXCR2PPARGCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040138287-A1 | Novel 5-phenyl-1h-indole derivatives as antagonists of interleukine-8 receptors | LABORATOIRES FOURNIER S.A. (FR) | 2004-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138287-A1 | Novel 5-phenyl-1h-indole derivatives as antagonists of interleukine-8 receptors | CXCL8, IL1RN, CCR8 | APOL1 3284/4885CXCR2 4/4885MTNR1A 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.