Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23306922 | 0.85 | CYP1A2 (0.39) | SLC6A4ACACBCYP1A2CYP2D6APEX1 | |
| SCHEMBL23306915 | 0.85 | CYP1A2 (0.39) | SLC6A4ACACBCYP1A2CYP2D6APEX1 | |
| SCHEMBL680253 | 0.85 | SLC6A2 (0.46) | SLC6A2SLC6A3SLC6A4ACACBGAA | |
| SCHEMBL23306930 | 0.84 | CYP1A2 (0.38) | SLC6A2SLC6A4CYP1A2CYP2D6APEX1 | |
| SCHEMBL18737749 | 0.83 | SIGMAR1 (0.43) | SLC6A2SLC6A3SLC6A4CYP2D6RAB9A | |
| SCHEMBL680890 | 0.81 | ACACB (0.44) | SLC6A2SLC6A3SLC6A4ACACBGAA | |
| SCHEMBL20892764 | 0.81 | ACACB (0.44) | SLC6A2SLC6A3SLC6A4ACACBGAA | |
| SCHEMBL684443 | 0.79 | ACACB (0.49) | SLC6A2SLC6A3SLC6A4ACACBGAA | |
| SCHEMBL13323478 | 0.79 | ACACB (0.49) | SLC6A2SLC6A3SLC6A4ACACBGAA | |
| SCHEMBL12871196 | 0.76 | NOS2 (0.52) | SLC6A2SLC6A3ACACBGAAFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |