Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.42 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.42 |
| ▸ | AKT2 | P31751 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12194476 | 0.87 | FFAR2 (0.38) | AKT1AKT3AKT2SMN1; SMN2FFAR2 | |
| SCHEMBL681180 | 0.86 | AKT1 (0.44) | AKT1AKT3AKT2SMN1; SMN2FFAR2 | |
| SCHEMBL12188337 | 0.83 | AKT1 (0.46) | AKT1AKT3AKT2SMN1; SMN2FFAR2 | |
| SCHEMBL12194498 | 0.82 | FFAR2 (0.41) | AKT3AKT2SMN1; SMN2FFAR2L3MBTL1 | |
| SCHEMBL681742 | 0.82 | AKT1 (0.41) | AKT1AKT3AKT2SMN1; SMN2FFAR2 | |
| SCHEMBL191445 | 0.81 | L3MBTL1 (0.51) | AKT1AKT3AKT2SMN1; SMN2FFAR2 | |
| SCHEMBL2738565 | 0.80 | AKT1 (0.43) | AKT1AKT3AKT2SMN1; SMN2FFAR2 | |
| Potassium Ion SCHEMBL191383 | 0.79 | AKT1 (0.43) | AKT1AKT3AKT2SMN1; SMN2FFAR2 | |
| SCHEMBL681142 | 0.78 | KMT2A (0.42) | FFAR2L3MBTL1POLBCYP2D6SLC6A2 | |
| SCHEMBL681371 | 0.78 | KMT2A (0.42) | FFAR2L3MBTL1POLBCYP2D6SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |