Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 14/20 | 0.61 |
| ▸ | RAB9A | P51151 | 12/20 | 0.61 |
| ▸ | POLB | P06746 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814883 | 0.87 | NPC1 (0.64) | NPC1RAB9APOLBKDM4EKMT2A | |
| SCHEMBL6810690 | 0.80 | POLB (0.63) | NPC1RAB9APOLBKDM4EKMT2A | |
| SCHEMBL6814602 | 0.77 | NPC1 (0.64) | NPC1RAB9APOLBKDM4EKMT2A | |
| SCHEMBL6814481 | 0.76 | NPC1 (0.73) | NPC1RAB9APOLBKDM4EKMT2A | |
| SCHEMBL6814478 | 0.75 | NPC1 (0.76) | NPC1RAB9APOLBKDM4EKMT2A | |
| SCHEMBL6814360 | 0.73 | NPC1 (0.76) | NPC1RAB9APOLBKDM4EKMT2A | |
| SCHEMBL6815339 | 0.73 | POLB (0.77) | NPC1RAB9APOLBKDM4EKMT2A | |
| SCHEMBL6818904 | 0.72 | RAB9A (0.78) | NPC1RAB9APOLBKDM4EKMT2A | |
| SCHEMBL2558347 | 0.72 | POLB (0.81) | NPC1RAB9APOLBKDM4EKMT2A | |
| SCHEMBL6814497 | 0.72 | POLB (0.75) | NPC1RAB9APOLBKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004012656-A2 | THIOPHENE AND FURAN DERIVATIVES AS PROSTAGLANDIN AGONISTS AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-02-12 | — | — | WO | disclosed |