Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679637 | 0.86 | AKT1 (0.45) | L3MBTL1AKT1AKT2AKT3HTT | |
| SCHEMBL681742 | 0.83 | AKT1 (0.41) | L3MBTL1AKT1AKT2AKT3HPGD | |
| SCHEMBL684413 | 0.83 | AKT1 (0.46) | L3MBTL1AKT1AKT2AKT3HTT | |
| SCHEMBL2738591 | 0.82 | AKT1 (0.46) | L3MBTL1AKT1AKT2AKT3HTT | |
| SCHEMBL12194498 | 0.81 | FFAR2 (0.41) | L3MBTL1AKT2AKT3HPGDPOLB | |
| SCHEMBL681157 | 0.80 | L3MBTL1 (0.45) | L3MBTL1ALDH1A1MAPTHPGDPOLB | |
| SCHEMBL12194476 | 0.78 | FFAR2 (0.38) | L3MBTL1AKT1AKT2AKT3HPGD | |
| SCHEMBL681545 | 0.77 | L3MBTL1 (0.40) | L3MBTL1AKT1AKT2AKT3ALDH1A1 | |
| SCHEMBL681680 | 0.77 | L3MBTL1 (0.40) | L3MBTL1AKT1AKT2AKT3ALDH1A1 | |
| SCHEMBL681135 | 0.77 | L3MBTL1 (0.40) | L3MBTL1AKT1AKT2AKT3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |