Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 7/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.33 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681744 | 1.00 | ADRB2 (0.40) | ADRB2ADRB1ADRB3MDM2KDM4E | |
| SCHEMBL679667 | 0.86 | ADRB2 (0.40) | ADRB2ADRB1ADRB3MDM2KDM4E | |
| SCHEMBL681005 | 0.86 | ADRB2 (0.40) | ADRB2ADRB1ADRB3MDM2KDM4E | |
| SCHEMBL681279 | 0.86 | LMNA (0.42) | ADRB2ADRB1LMNARAB9AMEN1 | |
| SCHEMBL12188385 | 0.85 | ADRB2 (0.41) | ADRB2ADRB1ADRB3MDM2KDM4E | |
| SCHEMBL12188387 | 0.85 | ADRB2 (0.41) | ADRB2ADRB1ADRB3MDM2KDM4E | |
| SCHEMBL17803802 | 0.85 | ADRB2 (0.41) | ADRB2ADRB1ADRB3KDM4EALDH1A1 | |
| SCHEMBL2738447 | 0.84 | ADRB2 (0.40) | ADRB2ADRB1ADRB3MDM2KDM4E | |
| SCHEMBL8220416 | 0.84 | ADRB2 (0.40) | ADRB2ADRB1ADRB3MDM2KDM4E | |
| SCHEMBL2738452 | 0.84 | ADRB2 (0.40) | ADRB2ADRB1ADRB3MDM2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |