Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 18/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.51 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.51 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6821494 | 0.88 | TBXA2R (0.53) | S1PR1TBXA2RPTGDRS1PR4ADORA3 | |
| SCHEMBL12923709 | 0.86 | KMT2A (0.49) | S1PR1TBXA2RPTGDR | |
| SCHEMBL1918972 | 0.85 | S1PR1 (0.75) | S1PR1S1PR4ADORA3S1PR5 | |
| SCHEMBL25147653 | 0.83 | SIRT1 (0.60) | S1PR1 | |
| SCHEMBL30762323 | 0.83 | SIRT1 (0.60) | S1PR1 | |
| SCHEMBL30762321 | 0.83 | SIRT1 (0.60) | S1PR1 | |
| SCHEMBL29141442 | 0.83 | SIRT1 (0.60) | S1PR1 | |
| SCHEMBL30762322 | 0.82 | S1PR1 (0.60) | S1PR1S1PR4ADORA3S1PR5 | |
| SCHEMBL2297254 | 0.82 | S1PR1 (0.60) | S1PR1S1PR4ADORA3S1PR5 | |
| SCHEMBL29141420 | 0.82 | S1PR1 (0.60) | S1PR1S1PR4ADORA3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1305286-B1 | CYCLOPENTANOINDOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK FROSST CANADA INC (CA) | 2004-12-08 | — | — | EP | disclosed |
| EP-1305286-A2 | CYCLOPENTANOINDOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK FROSST CANADA INC. (CA) | 2003-05-02 | — | — | EP | disclosed |
| US-6410583-B1 | PROSTAGLANDIN ANTAGONIST | MERCK FROSST CANADA & CO. (CA) | 2002-06-25 | — | — | US | disclosed |
| WO-2002008186-A2 | CYCLOPENTANOINDOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK FROSST CANADA & CO. (CA) | 2002-01-31 | — | — | WO | disclosed |