Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | STK17B | O94768 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.32 |
| ▸ | ACP1 | P24666 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6817843 | 0.89 | SCN9A (0.37) | KMT5ACRHR1STK17BSTK17ALRRK2 | |
| SCHEMBL6817679 | 0.88 | STK17B (0.35) | KMT5ABRD4STK17BSTK17ALRRK2 | |
| SCHEMBL6817533 | 0.85 | HSP90AA1 (0.37) | KMT5AHSP90AA1HSP90AB1CRHR1ACP1 | |
| SCHEMBL6821721 | 0.84 | NPC1 (0.34) | KMT5ABRD4LRRK2ACP1 | |
| SCHEMBL6822467 | 0.82 | KMT5A (0.34) | KMT5ABRD4TNFEHMT2ACP1 | |
| SCHEMBL6818015 | 0.81 | ACP1 (0.36) | KMT5ABRD4HSP90AA1HSP90AB1CRHR1 | |
| SCHEMBL6817777 | 0.79 | BRD4 (0.37) | BRD4CRHR1 | |
| SCHEMBL6814612 | 0.78 | BCHE (0.30) | ACHE | |
| SCHEMBL6813647 | 0.77 | ACP1 (0.43) | CRHR1ACP1 | |
| SCHEMBL6082536 | 0.77 | IDO1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004031189-A1 | PYRIDINO AND PYRIMIDINO PYRAZINONES FOR TREATMENT OF ANXIETY AND DEPRESSION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2004-04-15 | — | — | WO | disclosed |