Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 8/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | TP53 | P04637 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.65 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.65 |
| ▸ | RELA | Q04206 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | HPSE | Q9Y251 | 6/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6821837 | 0.88 | NPC1 (0.67) | NPC1KDM4EALDH1A1MAPK1RAB9A | |
| SCHEMBL6818279 | 0.87 | KDM4E (0.70) | NPC1KDM4EALDH1A1MAPK1RAB9A | |
| SCHEMBL14581704 | 0.87 | KDM4E (0.66) | NPC1KDM4EALDH1A1MAPK1RAB9A | |
| SCHEMBL6821781 | 0.86 | NPC1 (0.62) | NPC1KDM4EALDH1A1MAPK1RAB9A | |
| SCHEMBL6822259 | 0.85 | KDM4E (0.61) | NPC1KDM4EALDH1A1MAPK1RAB9A | |
| SCHEMBL6821845 | 0.85 | KDM4E (0.61) | NPC1KDM4EALDH1A1MAPK1RAB9A | |
| SCHEMBL5461475 | 0.85 | HPSE (0.72) | NPC1KDM4EALDH1A1RAB9AMAPT | |
| SCHEMBL6821886 | 0.84 | NPC1 (0.62) | NPC1KDM4EALDH1A1MAPK1RAB9A | |
| Methane SCHEMBL5476423 | 0.84 | HPSE (0.70) | NPC1KDM4EALDH1A1RAB9AMAPT | |
| SCHEMBL6818596 | 0.83 | MAPT (0.56) | NPC1KDM4EALDH1A1MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018177857-A1 | SYMMETRICAL 2-AMINOPHENYL-BENZAZOLYL-5-ACETATE COMPOUNDS AND THEIR USE AS ANTI-HEPARANASE | LEADIANT BIOSCIENCES SA IN LIQUIDAZIONE (CH) | 2018-10-04 | — | — | WO | disclosed |
| EP-3381907-A1 | SYMMETRICAL 2-AMINOPHENYL-BENZAZOLYL-5-ACETATE COMPOUNDS AND THEIR USE AS ANTI-HEPARANASE | Leadiant Biosciences SA (CH) | 2018-10-03 | — | — | EP | disclosed |
| WO-2004046122-A2 | BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE ACID DERIVATIVES AND THEIR USE AS HEPARANASE INHIBITORS | OXFORD GLYCOSCIENCES (UK) LTD (GB) | 2004-06-03 | — | — | WO | disclosed |