Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27742176 | 0.85 | PPARG (0.48) | ALDH1A1PPARGPPARALMNAKMT2A | |
| SCHEMBL681060 | 0.83 | HTRA1 (0.46) | ACACBSLC6A2SLC6A3GAAHTRA1 | |
| SCHEMBL681500 | 0.81 | SLC6A2 (0.46) | ACACBSLC6A2SLC6A3GAAPOLB | |
| SCHEMBL20892764 | 0.80 | ACACB (0.44) | ACACBSLC6A2SLC6A3GAAPOLB | |
| SCHEMBL680890 | 0.80 | ACACB (0.44) | ACACBSLC6A2SLC6A3GAAPOLB | |
| SCHEMBL681327 | 0.79 | GAA (0.51) | GAAALDH1A1KDM4ETSHR | |
| SCHEMBL681663 | 0.79 | BCHE (0.50) | POLBALDH1A1KMT2A | |
| SCHEMBL680893 | 0.79 | ACACB (0.39) | ACACBSLC6A2SLC6A3ALDH1A1HTT | |
| SCHEMBL680880 | 0.79 | GAA (0.44) | ACACBSLC6A2SLC6A3GAAALDH1A1 | |
| SCHEMBL12537186 | 0.79 | ACACB (0.57) | ACACBSLC6A2SLC6A3GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |