Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TACR2 | P21452 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681503 | 0.88 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1CNR1NPSR1TACR2 | |
| SCHEMBL681837 | 0.79 | ACACB (0.42) | GAAALDH1A1TSHRKDM4E | |
| SCHEMBL681663 | 0.79 | BCHE (0.50) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL14295176 | 0.76 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1CNR1NPSR1TACR2 | |
| SCHEMBL681060 | 0.75 | HTRA1 (0.46) | GAASMN1; SMN2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL20892764 | 0.75 | ACACB (0.44) | GAASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL680890 | 0.75 | ACACB (0.44) | GAASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL10266645 | 0.74 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1CNR1TACR2 | |
| SCHEMBL680880 | 0.74 | GAA (0.44) | GAASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL681500 | 0.73 | SLC6A2 (0.46) | GAASMN1; SMN2ALDH1A1TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |